| Date | Home | Away | Result |
|---|---|---|---|
| 11/21/25 1:30 PM | UD Las Palmas | Albacete Balompie | 2-1 |
| 11/22/25 9:15 AM | Andorra CF | CD Castellon | 1-3 |
| 11/22/25 11:30 AM | CD Leganes | UD Almeria | 0-3 |
| 11/22/25 11:30 AM | SD Eibar | Real Saragossa | 1-2 |
| 11/22/25 2:00 PM | FC Granada | Cordoba CF | 1-1 |
| 11/23/25 7:00 AM | Deportivo La Coruna | AD Ceuta FC | 2-1 |
| 11/23/25 9:15 AM | FC Cadiz | CyD Leonesa | 1-2 |
| 11/23/25 9:15 AM | SD Huesca | Sporting Gijon | 2-0 |
| 11/23/25 11:30 AM | Burgos CF | Racing Santander | 0-2 |
| 11/23/25 2:00 PM | FC Malaga | CD Mirandes | 3-2 |
| 11/24/25 1:30 PM | Real Sociedad B | Real Valladolid | 1-0 |